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Results: A Vision Transformed
Early Milestones
- Day 7: Jace blinked in response to a flashlight.
- Month 1: Recognized geometric shapes on a high-contrast screen.
- Month 6: Navigated a dimly lit room independently.
Quantitative Outcomes
- Visual Acuity: Improved from 20/2000 (light perception only) to 20/400 (legally blind but functional).
- Retinal Structure: OCT revealed a 20% increase in photoreceptor layer thickness.
Psychosocial Impact
- School Integration: Jace transitioned from Braille to large-print books.
- Family Bonds: His father shared, “The first time he saw his baby sister, he cried.”
Ethical and Practical Considerations
Balancing Risks and Benefits
- Risks: Retinal detachment (5% risk), inflammation, and transient intraocular pressure spikes.
- Benefits: Partial vision restoration and halted disease progression.
Cost and Accessibility
- Therapy Cost: Estimated at $750,000 per eye, limiting access without insurance or subsidies.
- Global Disparities: Developing nations lack infrastructure for gene therapy delivery.
Expert Insights
Dr. Aaron Patel, lead surgeon: “This isn’t a cure, but it’s a lifeline. Jace’s case proves that genetic blindness can be mitigated.”
